Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)

Central serous chorioretinopathy treatment with a systemic PDE5 and PDE6 inhibitor (sildenafil)

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Purpose: Examine the use of systemic phosphodiesterase inhibition (sildenafil) to clear keychron m6 mouse central serous chorioretinopathy (CSCR).Observations: In a long-standing CSCR patient, sildenafil produced a rapid resolution.When discontinued (dechallenge) the CSCR returned.

When rechallenged, the CSCR again rapidly e1504ga-ws34 disappeared and did not recur in 5 months of continued therapy.Conclusions: AND IMPORTANCE: Systemic sildenafil can cause rapid clearance of CSCR and can augment or replace other treatments.